一项全基因组关联研究确定了亚洲特异性遗传易感性对表观遗传年龄加速的研究
Kwangyeon Oh1,2, Dabin Yun1, Soyoun Yang1
1College of Pharmacy, Chungbuk National University, 194-21, Osongsaengmyeong-1 Ro, Heungdeok-Chungcheongbuk-Do, Cheongju, 28160, Korea.
GeroScience
|September 15, 2025
概括
这项研究确定了六种与表观遗传衰老加速 (EAA) 相关的亚洲特异性遗传变异,包括五种新的单核酸多态 (SNP). 这些发现突出了与祖先相关的生物学衰老和潜在治疗点的差异.
科学领域:
- 遗传学 遗传学 是一个
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 衰老研究研究 衰老研究
背景情况:
- 表观遗传钟测量生物年龄,了解像表观遗传年龄加速 (EAA) 这样的遗传影响至关重要.
- 全基因组关联研究 (GWAS) 已经探索了EAA的遗传基础,但种族变异需要进一步调查,特别是在亚洲人群中.
研究的目的:
- 在韩国人口中使用多个表观遗传钟进行EAA的GWAS.
- 确定与EAA相关的遗传变异,并在亚洲环境中探索它们的生物机制和临床影响.
主要方法:
- 在1962年韩国个体中使用五个表观遗传时钟 (Hannum,DNAm PhenoAge,GrimAge,Zhang2019,Horvath-Skin&Blood) 对EAA的GWAS分析.
- 进行了基因基因,通路丰富,qPCR和QTL分析.
- 进行了性和药物重定向分析.
主要成果:
- 六种SNP与EAA独立相关 (P < 5 × 10−8),其中包括欧洲人罕见的五种新型变异.
- DNAm PhenoAge-EAA与ASPA和SPATA22相关 (涉及亡);Zhang2019-EAA与单糖代谢中的基因相关.
- 与EAA相关的基因与PPAR-β/δ激动剂表现出亲和力;一个SNP在肝功能生物标志物中表现出性.
结论:
- 鉴定了导致EAA的亚洲特异性遗传变异,这表明表观遗传衰老的祖先相关差异.
- 发现了EAA,亡和肝功能之间的潜在联系,为东亚人口的衰老机制提供了洞察力.
- 突出了潜在的治疗点,如PPAR-β/δ激动剂,用于与年龄相关的疾病.
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