早期喉癌后的声音和吞结果:一项基于英国的多中心研究
M Bhabra1, D Sellstrom2, C Robertson3
1Department of Speech and Language Therapy, South Tyneside & Sunderland NHS Trust, Sunderland, UK.
概括
放射治疗为早期喉癌提供了比跨口激光微手术 (TLM) 更好的短期语音结果. 吞功能不受这两种治疗的影响,这凸显了功能性结果在决策中的重要性.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 在瘤学瘤学.
- 语音和语言治疗治疗
背景情况:
- 早期喉癌的治疗选择包括跨口激光微手术 (TLM) 和放射治疗,具有类似的瘤结果.
- 对TLM与放射治疗对语音和吞功能的比较影响尚未得到充分证实.
研究的目的:
- 为了前性地评估和比较TLM或放射治疗的早期喉癌患者的语音和吞结果.
- 在英国多中心环境中使用标准化的多维协议来评估功能恢复.
主要方法:
- 137名T1/T2喉癌患者在五个英国中心被招募.
- 进行的治疗是TLM或放射治疗 (高达55 Gy).
- 语音 (VHI-10,MPT,GRBAS) 和吞 (100mL水试验,NoD) 在基线,治疗后3个月和6个月被评估.
主要成果:
- 放射治疗显著改善了语音障碍指数得分和3个月的最大发音时间.
- 放射治疗后与3个月后的TLM相比,观察到降低了声.
- 在6个月内,治疗组之间没有发现吞功能或饮食正常性的显著差异.
结论:
- 与TLM相比,放射治疗在早期喉癌中显示出优异的短期语音结果.
- 吞功能似乎在很大程度上独立于选择的治疗方式.
- 功能性结果应成为早期喉癌治疗决策的组成部分.
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