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Updated: Jan 17, 2026

Evaluation of Substrate Ubiquitylation by E3 Ubiquitin-ligase in Mammalian Cell Lysates
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药物对CYP3A酶活性和蛋白质表达的作用通过Ubiquitination修改法规

Fang Wang1, Xiwei Gu1, Haiying Hong1

  • 1Department of Pharmacology, College of Pharmacy, Harbin Medical University, Harbin, Heilongjiang Province, China.

Basic & clinical pharmacology & toxicology
|September 16, 2025
PubMed
概括

药物代谢通过cytochrome P450 3A4 (CYP3A4) 在低氧状态下可能会受损. 缺氧加剧了药物诱导的CYP3A4抑制,可能增加毒性反应和药物相互作用.

关键词:
在 CYP3A4 中.药物代谢 药物代谢药物安全 药物安全酶抑制抑制酶的抑制无处不在的化

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