胸部辐射对晚期小细胞肺癌患者的存活的影响,这些患者接受了化疗免疫治疗
Yunbin Gao1,2, Xuyu Zhang1, Dawei Zhao1
1Department of Radiation Oncology, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China.
概括
将胸部放射治疗 (TRT) 添加到化疗免疫治疗中,显著改善了晚期小细胞肺癌 (AS-SCLC) 患者的无进展生存率和整体生存率. 这一发现表明TRT是AS-SCLC的有益治疗选择.
科学领域:
- 在瘤学瘤学.
- 辐射瘤学 辐射瘤学
- 肺部病理学 肺部病理学
背景情况:
- 胸部辐射疗法 (TRT) 是一种成熟的治疗方法,用于改善化疗后晚期小细胞肺癌 (AS-SCLC) 的结果.
- 与AS-SCLC现代化疗免疫疗法相结合的TRT的作用仍然是需要研究的领域.
研究的目的:
- 在AS-SCLC患者中比较含有和没有TRT的化疗免疫疗法的疗效.
- 确定影响AS-SCLC治疗结果的预后因素.
主要方法:
- 一项回顾性研究包括172名接受化疗免疫治疗的AS-SCLC患者,其中60人接受TRT,112人没有接受.
- 倾向性得分匹配 (1:1比) 用于最大限度地减少选择偏差.
- 卡普兰-梅尔分析,日志级别测试和考克斯回归模型评估了生存结果.
主要成果:
- 接受TRT的患者的整体存活时间 (24.2个月与15.9个月,P=0.006) 和无进展存活时间 (11.3个月与6.6个月,P<0.001) 显著增加.
- 多变量分析证实TRT是整体和无进展生存时间 (P=0.005和P<0.001分别) 的有利预后因素.
- 亚组分析表明,没有脑或骨转移的患者特别受益于TRT (P<0.001).
结论:
- 当TRT与化疗免疫疗法相结合时,与AS-SCLC患者的生存结果的改善有关.
- 这些发现支持将TRT纳入选择AS-SCLC患者的治疗方案.
- 建议通过潜在的随机试验进行进一步验证.
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