在aquaporin-4-IgG阳性 (AQP4-IgG+) NMOSD中的级联标志
Luigi Bonan1, Federico Camilli2, Marcello Bombardi1
1Dipartimento di Scienze Biomediche e Neuromotorie, Università di Bologna, Bologna, Italy.
Multiple sclerosis (Houndmills, Basingstoke, England)
|September 16, 2025
概括
级联标志,曾经认为是特定于神经贝切特的,可以模仿Aquaporin-4 IgG阳性神经omyelitis光谱障碍 (NMOSD) 中的病变. 这种成像发现可能会延迟NMOSD患者的诊断和治疗.
科学领域:
- 神经免疫学 神经免疫学
- 神经辐射学神经辐射学
- 神经学 神经学
背景情况:
- 布标志在历史上被认为是神经贝赫塞特病的病理标志.
- 在视神经炎 (NMO) 中,二脑半脑病变在2015年之前未被充分识别.
- 当前的诊断标准承认这些特定的损伤局部.
研究的目的:
- 报告一个Aquaporin-4IgG阳性神经omyelitis光学谱障碍 (NMOSD) 的病例.
- 为了突出描绘模仿级联符号的成像发现所带来的诊断挑战.
主要方法:
- 一个 AQP4-IgG+ NMOSD 患者的病例报告.
- 脑损伤的磁共振成像 (MRI) 分析.
- 临床表现包括急性横侧髓炎和视神经炎.
主要成果:
- 这位患者出现了急性横向髓炎和双边视神经炎.
- 早期的大脑MRI显示了相交的二脑中脑层病变,类似于级联标志.
- 这种成像模式最初表明了除了NMOSD之外的差异诊断.
结论:
- 在MRI上的级联标志在AQP4-IgG+ NMOSD中可能会误导.
- 这种成像模仿可能会阻碍准确的差异诊断.
- 延迟诊断可能导致延迟启动适当的NMOSD治疗.
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