高剂量流感疫苗适用于老年人:仔细研究现实世界的数据
Laura Colombo1, Anna Elisabeth Steinberg2, Sanjay Hadigal3
1Global Medical Affairs, Viatris, Milan, Italy.
Current medical research and opinion
|September 16, 2025
概括
高剂量流感疫苗为75岁及以上的成年人提供了增强的保护. 标准剂量疫苗为年轻的老年人 (65-74岁) 提供可靠的保护,并且仍然是一个具有成本效益的选择.
科学领域:
- 老年学是指老年学的学科.
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
背景情况:
- 老年人面临更高的流感风险,需要有效的疫苗接种策略.
- 在某些地区,建议使用高剂量 (HD) 流感疫苗,以加强对这一人口群体的保护.
- 有证据表明,HD疫苗的益处在75岁及以上的个体中最为明显.
研究的目的:
- 审查现实世界的有效性数据,比较老年人群中的高发病疫苗和标准剂量 (SD) 流感疫苗.
- 评估老年人群中不同年龄层的HD与SD流感疫苗的比较有效性.
- 为老年人提供有关最佳流感疫苗选择的疫苗接种政策的信息.
主要方法:
- 对现实世界观测研究的系统审查.
- 对HD与SD流感疫苗的有效性比较分析.
- 年龄分层分析侧重于65-74岁和75岁以上的年龄组.
主要成果:
- 在75岁及以上的个体中,高发性流感疫苗表现出一致的有效性优势.
- 在65-74岁的年龄组中,对HD疫苗优于SD疫苗的证据有限,并且往往没有统计学意义.
- SD疫苗为60-74岁的成年人提供了实质性和可靠的保护.
结论:
- 量身定制的疫苗接种方法,建议在75岁以上的人群中接种HD疫苗,在65-74岁的人群中接种SD疫苗,可以优化保护和覆盖率.
- 对于大多数老年人,特别是60-74岁的老年人来说,SD疫苗是一种有效和可获得的选择.
- 需要进一步的年龄分层实验研究来完善老年人流感疫苗接种政策.
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