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Updated: Jan 17, 2026

Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model
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Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model

Published on: June 6, 2025

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能否R-胺和沃尔夫拉姆综合征为了解抑郁症和自杀倾向提供信息? 一个基于Sigma-1受体的视角

Hans O Kalkman1, Lukasz Smigielski1

  • 1Department of Child and Adolescent Psychiatry and Psychotherapy, University Hospital of Psychiatry, University of Zurich, Zurich, Switzerland.

Human psychopharmacology
|September 16, 2025
PubMed
概括

沃尔夫拉姆综合征是由WFS1突变引起的,涉及到内质网膜-线粒体功能障碍. 西格玛-1受体激素PRE084在动物模型中恢复了功能,这表明了潜在的治疗途径.

关键词:
凯胺的反复分子是凯胺的反复分子.线粒体相关的ER膜与线粒体相关.神经元中的Ca2+传感器-1自杀 自杀 自杀 自杀 自杀 自杀 自杀沃尔夫拉明胺是一种一个 σ1 激动剂.

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