抗抑郁药引起的性功能障碍的管理:文学综述
Faith D Tran1, Gregory H Bichai1, Zachary Kravetz2
1Psychiatry, Florida Atlantic University Charles E. Schmidt College of Medicine, Boca Raton, USA.
Cureus
|September 16, 2025
概括
选择性血清素再吸收抑制剂 (SSRI) 可能导致性副作用. 切换抗抑郁药物或添加某些药物,如布洛普和沙弗朗,可能有助于管理抗抑郁药引起的性功能障碍 (AISD).
科学领域:
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
- 性医学性医学性医学性医学
背景情况:
- 选择性血清素再吸收抑制剂 (SSRI) 是抑郁症和焦虑症的主要治疗方法.
- 性副作用,包括性欲下降和高潮功能障碍,是SSRI常见的不良影响.
- 抗抑郁药引起的性功能障碍 (AISD) 可能会对治疗坚持和生活质量产生负面影响.
研究的目的:
- 审查切换抗抑郁药疗法的有效性或为管理AISD添加辅助治疗.
- 探索SSRI诱导性功能障碍的潜在药理和草药干预措施.
主要方法:
- 对PubMed (1996-2023) 的英语文章进行了叙事审查.
- 搜索了讨论抗抑郁药引起的性功能障碍及其管理的研究.
- 专注于转换抗抑郁药物或辅助疗法的精选文章.
主要成果:
- 转换为抗抑郁药物,如米尔塔扎,纳法佐或伏尔托克塞丁,可能有利于一些患者.
- 辅助布洛普和番石榴 (Crocus sativus) 在治疗AISD方面表现有前途.
- 维拉佐和金科比洛巴的证据是相互矛盾的;对其他辅助治疗需要更多的研究.
结论:
- 切换或增强抗抑郁药物治疗可以是有效的策略来管理AISD.
- 布普罗皮昂和沙夫兰是潜在的选择,但许多干预措施需要进一步研究.
- 需要更多的研究来了解AISD病理生理学,并开发更广泛的管理选择.
更多相关视频
08:15Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model
Published on: June 6, 2025
527
04:33Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression
Published on: April 26, 2024
1.2K
相关概念视频
01:23Antidepressant Drugs: MAOIs and Other Agents
828
Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
828
01:25Antidepressant Drugs: Overview
1.4K
Antidepressant drugs are a class of medications primarily used for treating various mood disorders, including major depression, anxiety disorders, and other related conditions. These medicines work by modulating the neurotransmitter balance within the brain, alleviating depressive symptoms. Antidepressants can be broadly categorized into several groups according to their mechanism of action and chemical structure: Selective Serotonin Reuptake Inhibitors (SSRIs), Serotonin-Norepinephrine...
1.4K
01:28Antidepressant Drugs: Tricyclics, SSRIs, and SNRIs
1.4K
Tricyclic Antidepressants (TCAs), including Desipramine (Norpramin), Imipramine (Tofranil), Clomipramine (Anafranil), and Amitriptyline (Elavil), inhibit serotonin and norepinephrine reuptake and also block other receptors. They are used for depression, pain conditions, and insomnia. Common adverse effects include anticholinergic effects, sedation, orthostatic hypotension, and weight gain. They have a narrow therapeutic window and so require plasma-level monitoring. Abrupt discontinuation can...
1.4K
01:08Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment
257
Hepatic impairment, characterized by decreased liver function, does not uniformly mandate adjustments in drug dosage. Whether dosage modifications are necessary depends on various factors related to the drug's metabolism and elimination pathways. If a drug is primarily excreted via the kidneys and bypasses significant hepatic processing, if it undergoes minimal metabolic transformation in the liver, or if it is volatile and primarily expelled through the lungs, dose adjustments may not be...
257
01:17Male Sexual Response: Erection & Ejaculation
19.1K
Sexual stimulation can take various forms, such as physical touch and visual or auditory cues. When this happens, the parasympathetic reflex in the sacral portion of the spinal cord is activated. This reflex stimulates the release of nitric oxide (NO), which then dilates the arterioles in the penis, increasing blood flow to the erectile tissues - the corpora cavernosa and corpus spongiosum.
The blood filling the erectile tissues compresses the veins, which helps to prevent blood from leaving...
The blood filling the erectile tissues compresses the veins, which helps to prevent blood from leaving...
19.1K
01:23Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists
900
Serotonin, a crucial neurotransmitter synthesized by enterochromaffin cells, plays a cardinal role in regulating gastrointestinal (GI) motility. With over 90% of the body's total serotonin in the GI tract, its influence on digestive processes is profound. Serotonin is swiftly released upon various stimuli, such as food boluses or certain drugs, triggering intrinsic sensory neurons in the myenteric plexus and extrinsic vagal and spinal sensory neurons. This leads to the activation of the...
900