阻塞性睡眠呼吸暂停和反流性疾病之间的关联:系统性审查和元分析
Xiangxia Zeng1,2, Shijia Wang1,2, Peiting Zhang1,2
1Department of Nutrition, School of Public Health, Guangzhou Medical University, Guangzhou, 511436, People's Republic of China.
Nature and science of sleep
|September 16, 2025
概括
阻塞性睡眠呼吸暂停 (OSA) 和胃食道逆流性疾病 (RD) 显示出潜在的联系,但这种联系在统计学上并不显著. RD影响睡眠效率,但其对OSA严重性的影响尚不清楚.
科学领域:
- 睡眠医学 睡眠医学
- 胃肠病学 胃肠病学
- 肺部病理学 肺部病理学
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 和胃食道逆流性疾病 (RD) 是影响健康和睡眠的常见疾病.
- 有证据表明OSA和RD之间存在联系,但这种关系需要进一步澄清.
研究的目的:
- 系统地审查和元分析OSA和RD之间的关联.
- 评估OSA患者的RD发病率和RD对睡眠参数的影响.
主要方法:
- 在PubMed,Embase,Cochrane图书馆和Scopus的系统搜索.
- 包括调查OSA-RD关联的成人研究.
- 评估了RD发生率,睡眠阶段,呼吸暂停严重程度和爱普沃思睡眠度量表 (ESS).
主要成果:
- 包括49项研究;在OSA和RD发病率增加之间,有一个温和的,无意义的关联 (RR 1.23,p=0.056).
- 在严重的OSA中增加反流症状的趋势 (p=0.036).
- RD显著降低了睡眠效率 (p=0.003) 和氧和 (p<0.001).
结论:
- 观察到OSA和RD之间的关联,但缺乏统计学意义.
- RD与睡眠效率降低有显著的相关性;与OSA严重程度没有明确的联系.
- 需要进一步的研究来定义OSA-RD关系.
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