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创伤性脑损伤的鼻内输送系统:进展和前景

Shin Hyuk Yoo^1,2, Soon Chul Heo^2,3, Jun Sang Bae¹

¹Department of Otorhinolaryngology, Dankook University College of Medicine, Cheonan, Republic of Korea.

Journal of tissue engineering

|September 16, 2025

概括

内鼻分娩通过直接进入大脑为治疗创伤性脑损伤 (TBI) 提供了一个有前途的途径. 本综述探讨了用于TBI治疗的鼻内系统的进展.

科学领域:

神经科学是一个神经科学.
药理学药理学是指药理学的学科.
生物医学工程生物医学工程

背景情况:

创伤性脑损伤 (TBI) 是导致死亡和残疾的重要原因,导致持久的认知,感官运动和人格缺陷.
目前的神经保护药物在临床上表现出有限的成功,尽管临床前结果充满希望.
血脑屏障限制了有效的药物输送到大脑.

研究的目的:

审查用于治疗创伤性脑损伤 (TBI) 的鼻内输送系统的当前进展.
突出鼻内输送作为TBI安全和有效的治疗策略的潜力.
讨论未来的临床前景和TBI通过鼻内治疗的新兴趋势.

主要方法:

对TBI和鼻内药物输送系统的当前文献的综述.
对TBI分子和细胞的鼻内输送进行临床前研究 (体外和体内动物模型) 的分析.
检查TBI治疗的临床前景和未来趋势.

主要成果:

鼻内输送绕过了血脑屏障,提供了直接进入大脑膜的途径.
最近的发展表明,在临床前的TBI模型中,鼻内输送系统的有效性.
目前正在研究各种分子和基于细胞的疗法,用于鼻内注射.

结论:

鼻内输送为TBI治疗提供了有利和安全的方法.
对于有效的TBI治疗来说,进一步的研究和鼻内输送系统的临床翻译至关重要.
新兴趋势表明,在管理TBI结果方面,鼻内输送具有显著的潜力.

关键词:

鼻内输送是指鼻内输送.纳米颗粒是一种纳米粒子.复兴再生是一种再生方式.干细胞是干细胞的组成部分.创伤性脑损伤是一种创伤性脑损伤

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