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Updated: May 31, 2026

Whole-body Mass Spectrometry Imaging by Infrared Matrix-assisted Laser Desorption Electrospray Ionization IR-MALDESI
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主要有限的皮肤性 Amyloidosis 的空间新陈代谢基于质谱成像

Xinyue Liu1, Zhijun Deng2, Ziyi Wan1

  • 1Dermatology Hospital, Southern Medical University, Guangzhou, China.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology
|September 16, 2025
PubMed
概括

代谢失调,特别是在氨酸代谢中,与原发性有限皮肤性粉症 (PLCA) 有关. 这项研究确定了在PLCA患者中促进皮肤粉样蛋白沉积的关键代谢物和途径.

关键词:
氨基化物 氨基化物在阿根廷,阿根廷人.质谱仪成像成像 质谱仪成像成像代谢生物组的代谢生物组原发性局部皮肤性粉样化症.

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相关概念视频

Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining, normally used to...