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Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...

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可注射的以溶剂为基础的离子凝,具有快速凝和广泛的血静功能.

Jia-Yu Yang1, En-Yu Zhou1, Ting-Hui Cheng1

  • 1Institute of Medical Science and Technology, National Sun Yat-sen University, College of Medicine, Kaohsiung, 80424, Taiwan.

Advanced healthcare materials
|September 16, 2025
PubMed
概括
此摘要是机器生成的。

一种新型的深溶解剂 (DES) 离子凝提供了快速有效的血液静止. 这种先进的水凝表现出强大的组织粘附性,抗菌性质,并在体内显著减少血液流失.

关键词:
它是一种抗菌药物,具有抗菌作用.生物相容性 生物相容性深层欧特克溶剂溶剂的使用血液静止 血液静止 血液静止离子凝凝 离子凝组织粘附 组织粘附

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科学领域:

  • 生物材料科学 生物材料科学
  • 化学工程是化学工程的重要组成部分.
  • 医疗器械 医疗器械

背景情况:

  • 在紧急医疗和外科手术中,有效的血液静止是至关重要的.
  • 当前的静血剂通常在有效性,应用或生物相容性方面存在局限性.

研究的目的:

  • 开发和描述一种新的无水离子凝,用于先进的静血应用.
  • 评估凝的物理,机械,抗菌,细胞相容性和静血性质.

主要方法:

  • 使用胆化物,乙烯基醇和聚烯酸配制含添加剂的深溶解剂 (DES) 离子凝.
  • 在现场凝,机械测试,膨胀,光学清晰度和热稳定性评估.
  • 抗菌检测,细胞相容性研究,体外血静性评估和体内动物模型 (老鼠尾巴截肢,肝脏穿刺).

主要成果:

  • 该DES离子凝表现出快速的in situ凝 (<10秒),高粘度和强大的组织粘附性.
  • 该DES-2% HEC配方在胀,光学清晰度 (>90%) 和热稳定性 (T10% = 131°C) 中表现最佳.
  • 在体内观察到血液损失和凝血时间的显著减少 (≈60-70%),具有强大的抗菌作用和出色的细胞相容性.

结论:

  • 开发的DES离子凝是一种有前途的多功能静血剂.
  • 它的快速作用,机械完整性,生物相容性和有效性使其适用于先进的静血应用.
  • 这种创新的水凝平台有可能改善紧急护理和手术结果.