预测青少年情绪障碍风险的遗传因素
Swathi Hassan Gangaraju1, Christel M Middeldorp1,2,3,4,5, Enda M Byrne1
1The University of Queensland, Child Health Research Centre, Brisbane, Australia.
Current opinion in psychiatry
|September 16, 2025
概括
遗传因素显著增加了青少年情绪障碍的风险,如抑郁症和双相情感障碍. 多基因风险评分 (PRS) 和家族遗传风险评分 (FGRS) 有助于预测发病和理解起源.
科学领域:
- 精神病学是一个精神病学.
- 遗传学 是一个遗传学.
- 青少年健康 青少年健康
背景情况:
- 青春期是情绪障碍发病的关键时期,遗传因素起着重要作用.
- 情绪障碍是高度遗传的,具有较高遗传风险的个体往往会更早出现情绪障碍.
- 了解遗传贡献对于解决青少年情绪障碍至关重要.
研究的目的:
- 审查了解导致青少年情绪障碍的遗传因素的最新进展.
- 总结遗传倾向如何影响青春期情绪障碍的发展和表现.
- 探索遗传风险评分在预测情绪障碍发作和过程中的有用性.
主要方法:
- 对检查情绪障碍遗传倾向的横截面和纵向研究的综述.
- 多基因风险评分 (PRS) 的分析,聚合多个遗传变异的影响.
- 包括遗传信息设计,包括家庭遗传风险评分 (FGRS),以调查风险因素关联.
主要成果:
- 有情绪症状的青少年对情绪和其他精神疾病的多基因风险更高.
- 多基因风险评分 (PRS) 改善双相情感障碍风险预测,当与临床和环境因素相结合时.
- 同龄人对抑郁症的遗传脆弱性增加了青少年自身的抑郁风险,表明了环境影响.
结论:
- 青少年发病的情绪障碍与较晚发病的情绪障碍相比,与增加的遗传风险有关.
- 多基因风险评分 (PRS) 和家族遗传风险评分 (FGRS) 显示出在青少年中预测情绪障碍发病和过程的潜力.
- 将遗传数据与环境因素相结合,可以增强预测模型,并阐明青少年情绪障碍的病因.
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