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Updated: Jan 17, 2026

Formulating and Characterizing Lipid Nanoparticles for Gene Delivery using a Microfluidic Mixing Platform
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基于多糖醇的脂质:在脂质纳米颗粒中的下一代PEG替代品,用于先进的药物输送系统

Yara Ensminger1, Rashmi Rashmi1, Michael Karimov2

  • 1Institute For Chemistry and Biochemistry, Freie Universität Berlin, Berlin, Germany.

Macromolecular rapid communications
|September 16, 2025
PubMed
概括

线性多糖醇 (lPG) 在脂质纳米粒子 (LNP) 中为mRNA输送提供了聚乙烯糖醇 (PEG) 的替代品. lPG功能化的LNP避免了抗PEG抗体,保持了与PEG化系统相比的转染效率.

关键词:
基因传递 基因传递 基因传递脂质纳米颗粒的使用方法挂替换是一种挂替换.聚糖醇多聚糖醇的使用方法

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