探索多发性硬化症相关的嗅觉障碍中的鼻子结构微生物相互作用
Zidan Gao1, Zhuoma Danzhen2, Yao Li3
1Department of Neurology, Affiliated Hospital of Guizhou Medical University, Guizhou Medical University, Guiyang City, Guizhou Province, China.
Annals of clinical and translational neurology
|September 16, 2025
概括
多发性硬化症 (MS) 患者表现出鼻腔细菌的改变,可能与嗅觉丧失和结构变化有关. 在MS患者中,prevotella buccalis可能与嗅觉功能障碍相关.
科学领域:
- 神经学 神经学
- 微生物学 微生物学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 嗅觉功能障碍在多发性硬化症 (MS) 中很常见,但人们对其了解甚少.
- 没有先前的研究研究了MS患者的鼻腔粘膜微生物群.
- 这项研究探讨了MS中嗅觉功能,鼻子微生物和轮体积之间的联系.
研究的目的:
- 调查多发性硬化症患者的嗅觉功能,鼻子微生物群组成和高级轮体积之间的关系.
- 确定与成员国嗅觉障碍相关的潜在微生物生物标志物.
主要方法:
- 一项单中心观察性研究,涉及42名多发性硬化患者和37名健康对照人群 (HC).
- 使用宾夕法尼亚大学气味识别测试 (UPSIT) 评估的嗅觉功能.
- 进行了深鼻微生物群分析和基于MRI的高级轮体积测量.
主要成果:
- 患有较低UPSIT分数的多发性硬化症患者的Prevotella buccalis丰度减少.
- 在健康对照组中,UPSIT得分与轮体积的优异性呈正相关;在MS患者中,这种相关性不存在.
- 在MS患者中,高轮体积与几种细菌属 (Cupriavidus,Methylobacterium-Methylorubrum,Ideonella,Acinetobacter) 有负相关.
结论:
- 鼻腔微生物群的变化可能与MS的嗅觉功能障碍和粘膜变化有关.
- 普雷沃特拉·布卡利斯 (Prevotella buccalis) 是MS中嗅觉障碍的潜在微生物相关物,尽管其作用需要进一步调查.
- 需要进行更大规模的研究来确定因果关系,并探索多发性硬化症患者鼻腔微生物组特征的诊断/治疗潜力.
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