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相关概念视频

Olfactory Receptors: Location and Structure01:03

Olfactory Receptors: Location and Structure

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The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
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Olfaction01:25

Olfaction

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The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...
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Physiology of Smell and Olfactory Pathway01:20

Physiology of Smell and Olfactory Pathway

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Humans detect odors with the help of specialized cells located in the upper part of the nasal cavity, called olfactory receptor neurons (ORNs). ORNs possess hair-like structures called cilia, which are receptive to sensations from the inhaled air. When an odorant molecule binds to a specific receptor on the cell of the cilia, it leads to a series of events that ultimately cause the ORN to send electrical signals to the olfactory bulb in the brain through the olfactory nerves.
The olfactory...
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The nose is composed of an observable exterior segment (external nose) and an internal segment within the skull known as the nasal cavity (internal nose). The external nose, visible on the face, consists of a framework of bone and hyaline cartilage enveloped in skin and muscle and lined with a mucous membrane. This structure is supported by the frontal bone, nasal bones, and maxillary bone and is supplemented by a cartilaginous framework comprising the septal nasal cartilage, lateral nasal...
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Olfactory Neurons Obtained through Nasal Biopsy Combined with Laser-Capture Microdissection: A Potential Approach to Study Treatment Response in Mental Disorders
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探索多发性硬化症相关的嗅觉障碍中的鼻子结构微生物相互作用.

Zidan Gao1, Zhuoma Danzhen2, Yao Li3

  • 1Department of Neurology, Affiliated Hospital of Guizhou Medical University, Guizhou Medical University, Guiyang City, Guizhou Province, China.

Annals of clinical and translational neurology
|September 16, 2025
PubMed
概括

多发性硬化症 (MS) 患者表现出鼻腔细菌的改变,可能与嗅觉丧失和结构变化有关. 在MS患者中,prevotella buccalis可能与嗅觉功能障碍相关.

关键词:
这是一个UPSITUPSITUPSIT.多发性硬化症多发性硬化症鼻子中的微生物群嗅觉障碍是一种嗅觉障碍.高级轮机组 优质轮机组

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科学领域:

  • 神经学 神经学
  • 微生物学 微生物学
  • 耳鼻喉科 耳鼻喉科 耳鼻喉科

背景情况:

  • 嗅觉功能障碍在多发性硬化症 (MS) 中很常见,但人们对其了解甚少.
  • 没有先前的研究研究了MS患者的鼻腔粘膜微生物群.
  • 这项研究探讨了MS中嗅觉功能,鼻子微生物和轮体积之间的联系.

研究的目的:

  • 调查多发性硬化症患者的嗅觉功能,鼻子微生物群组成和高级轮体积之间的关系.
  • 确定与成员国嗅觉障碍相关的潜在微生物生物标志物.

主要方法:

  • 一项单中心观察性研究,涉及42名多发性硬化患者和37名健康对照人群 (HC).
  • 使用宾夕法尼亚大学气味识别测试 (UPSIT) 评估的嗅觉功能.
  • 进行了深鼻微生物群分析和基于MRI的高级轮体积测量.

主要成果:

  • 患有较低UPSIT分数的多发性硬化症患者的Prevotella buccalis丰度减少.
  • 在健康对照组中,UPSIT得分与轮体积的优异性呈正相关;在MS患者中,这种相关性不存在.
  • 在MS患者中,高轮体积与几种细菌属 (Cupriavidus,Methylobacterium-Methylorubrum,Ideonella,Acinetobacter) 有负相关.

结论:

  • 鼻腔微生物群的变化可能与MS的嗅觉功能障碍和粘膜变化有关.
  • 普雷沃特拉·布卡利斯 (Prevotella buccalis) 是MS中嗅觉障碍的潜在微生物相关物,尽管其作用需要进一步调查.
  • 需要进行更大规模的研究来确定因果关系,并探索多发性硬化症患者鼻腔微生物组特征的诊断/治疗潜力.