在中国汉族人口中,LINC-PINT多态对HNSCC风险的影响
Lingyu Kong1,2,3, Wenjing Wang1,2,3, Hang Meng1,2,3
1Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Life Sciences, Northwest University, Xi'an, Shaanxi, 710069, China.
Die Naturwissenschaften
|September 16, 2025
概括
在LINC-PINT (长跨基因非蛋白编码RNA,PINT) 中的遗传变异与中国汉族人群中头部和部状细胞癌 (HNSCC) 风险增加有关. 像rs157916,rs16873842和rs7781295这样的特定多态性与HNSCC易感性有关.
科学领域:
- 遗传学 是一个遗传学.
- 在瘤学瘤学.
- 分子生物学分子生物学
背景情况:
- 头部和部状细胞癌 (HNSCC) 是一种流行的恶性瘤.
- 遗传遗传因素对HNSCC发展具有不可修改的风险.
- 了解遗传倾向对于HNSCC风险评估至关重要.
研究的目的:
- 调查LINC-PINT基因多态化与中国汉族人群中HNSCC敏感性之间的关联.
- 为了确定可能影响HNSCC风险的特定LINC-PINT变体.
- 探索基于LINC-PINT基因型的HNSCC潜在的预测模型.
主要方法:
- 从524名HNSCC患者和517名健康对照人群中提取了基因组DNA.
- LINC-PINT多态系的基因型被测定,并分析了与HNSCC风险的关联.
- 用物流回归分析和分层分析来评估数据.
主要成果:
- 单个核酸多态体rs157916,rs16873842和rs7781295显著与增加的HNSCC易感性有关.
- 根据年龄,性别和SCC亚型 (如甲状腺,鼻) 的亚组,特定的多态性显示HNSCC风险增加.
- 对rs7801029和rs7781295的综合分析表明了作为HNSCC的预测模型的潜力.
结论:
- LINC-PINT基因多态可能与患上HNSCC的风险增加有关.
- 某些LINC-PINT变异可能作为HNSCC易感性的遗传标记.
- 进一步的研究可以验证这些发现,并探索LINC-PINT在HNSCC病变发生中的作用.
相关概念视频
01:05Single Nucleotide Polymorphisms-SNPs
17.9K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
17.9K
02:39lncRNA - Long Non-coding RNAs
9.8K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
9.8K
03:18Non-LTR Retrotransposons
13.2K
As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
13.2K