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Updated: Jul 19, 2026

A Proinflammatory, Degenerative Organ Culture Model to Simulate Early-Stage Intervertebral Disc Disease.
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针对RIPK1的治疗可通过抑制核脉PANoptosis抑制椎间盘退化来缓解椎间盘退化

Zhenyu Zhu1, Fanqi Kong1, Feng Jiang2

  • 1Department of Orthopedic Surgery, Changzheng Hospital, Navy Medical University, No. 415 Fengyang Rd, Shanghai, 200003, People's Republic of China.

Apoptosis : an international journal on programmed cell death
|September 16, 2025
PubMed
概括

椎间盘退化 (IVDD) 与RIPK1.1介导的编程细胞死亡 (PCD) 有关. 用抑制剂3-47向RIPK1显示了通过抑制RIPK1介导的PANoptosis来缓解IVDD的治疗潜力.

关键词:
椎间盘退化 椎间盘退化它的核心是脉的.这就是PANoptosis.在RIPK1中使用.小分子抑制剂小分子抑制剂

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