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与免疫检查点抑制剂相关的神经病变

Gabriel de Deus Vieira¹, Vinícius de Oliveira Boldrini², Luana Schlindwen³

¹Brazilian Institute of Neuroscience and Neurotechnology, University of Campinas, Campinas, Brazil; Department of Neurology, University of the Joinville Region, Joinville, Brazil.

Journal of neuroimmunology

|September 16, 2025

概括

免疫检查点抑制剂 (ICI) 通过增强免疫细胞来治疗癌症,但可以引起神经系统的副作用. 本综述侧重于接受ICI癌症治疗的患者的头骨神经问题.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
神经学神经学

背景情况:

作为免疫检查点抑制剂 (ICI),单克隆抗体 (mAbs) 是一种关键的癌症治疗方法.
通过逆转T细胞和NK细胞耗尽,ICI可以增强抗瘤免疫力.
治疗ICI可能会导致与免疫相关的不良事件,影响各种器官,包括神经系统.

研究的目的:

在接受ICI治疗的癌症患者中,审查神经干扰作为神经系统病变的表现.

主要方法:

关于免疫检查点抑制剂和神经系统不良事件的研究文献综述.
专注于病例报告和详细介绍神经神经病变的临床研究.

主要成果:

神经干扰是ICI治疗中已知的神经复杂症.
这些事件表现为神经系统内的特定病变.
了解这些模式有助于诊断和管理.

结论:

免疫检查点抑制剂提供向癌症治疗,但存在神经系统不良事件的风险.
神经受影响是ICI诱导的神经毒性的显著表现.
需要进一步研究以阐明这些并发症的机制并优化这些并发症的管理.

关键词:

头骨神经头骨神经头骨神经免疫检查点抑制剂免疫检查点抑制剂与免疫相关的不良事件.单克隆抗体是一种单克隆抗体.

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