相关实验视频
Updated: Jan 17, 2026

08:18
Preparation of Naringenin Solution for In Vivo Application
Published on: August 10, 2021
3.8K
口服营养药物干预改善内皮功能:来自体外和试点临床研究的证据
Vincenza Valerio1, Veronika A Myasoedova1, Ilaria Massaiu1
1Centro Cardiologico Monzino IRCCS, Milan 20138, Italy.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
|September 16, 2025
概括
生物活性化合物的组合通过减少氧化应激和增强氧化 (NO) 生产,改善了血管健康. 这种补充剂在试点研究中增强了内皮功能并减少了动脉硬性.
科学领域:
- 心血管研究研究心血管研究
- 内皮细胞生物学 内皮细胞生物学
- 营养学科学 营养学科学
背景情况:
- 大动脉硬化影响超过30%的65岁以上的人,增加了冠状动脉疾病和大动脉狭窄的风险.
- 由氧化应激,氧化物 (NO) 信号受损,炎症和脂蛋白沉积驱动的内皮功能障碍是心血管疾病发病和进展的关键因素.
研究的目的:
- 研究生物活性化合物 (长,辅酶Q10,黑,维生素B1,维生素D3) 组合的潜力,以抵消内皮功能障碍的机制.
- 评估这些化合物对血管健康标志物的影响,无论是在体外还是在人类临床试点研究中.
主要方法:
- 对大动脉内皮细胞进行体外试验,以测量细胞活力,活性氧物种 (ROS) 和NO水平.
- RNA测序用于分析与抗动脉样硬化,抗氧化和抗炎途径相关的基因表达.
- 在健康志愿者中进行了一项为期4周的前性试点临床研究,以评估内皮功能和动脉硬性.
主要成果:
- 在体外,这些化合物显著降低了ROS的产生,提高了内皮活力和NO水平.
- 基因表达分析显示了关键的抗动脉样硬化,抗氧化和抗炎基因的上调.
- 从临床角度来看,补充剂在所有受试者中改善了先前存在的功能障碍和降低了动脉硬性的参与者中的内皮功能,没有任何不良影响.
结论:
- 通过口服补充这种生物活性化合物组合,证明了对心血管健康的潜在治疗益处.
- 这些发现表明,改善内皮功能和血管健康的方法很有希望,特别是在内皮功能障碍患者中.
相关概念视频
Nitric Oxide Signaling Pathway
6.2K
Nitric oxide (NO), an inorganic gas, acts as a potent second messenger in most animal and plant tissues. NO diffuses out of the cells that produce it and enters the neighboring cells to generate a downstream response. NO synthase (NOS) catalyzes NO production by the deamination of the amino acid arginine. There are three isoforms of NOS. Endothelial cells have endothelial NOS (eNOS), nerve and muscle cells have neuronal NOS (nNOS), and macrophages produce inducible NOS (iNOS) upon exposure...
6.2K
Atherosclerosis III: Management
322
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
322
Antianginal Drugs: Nitrates and β-Blockers
1.4K
In cardiovascular health, antianginal drugs combat angina pectoris — a condition marked by chest pain owing to diminished blood flow to the heart.
Organic nitrates, such as nitroglycerin, play a pivotal role. Once metabolized, they liberate nitric oxide, a molecular marvel. Nitric oxide triggers guanylyl cyclase and augments cGMP production. This biochemical cascade orchestrates the relaxation of vascular smooth muscles, ushering in vasodilation and enhancing coronary blood flow....
Organic nitrates, such as nitroglycerin, play a pivotal role. Once metabolized, they liberate nitric oxide, a molecular marvel. Nitric oxide triggers guanylyl cyclase and augments cGMP production. This biochemical cascade orchestrates the relaxation of vascular smooth muscles, ushering in vasodilation and enhancing coronary blood flow....
1.4K
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
644
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
644
Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists
465
Prostacyclin receptor agonists are a class of therapeutic agents integral to managing pulmonary arterial hypertension (PAH). These drugs operate by mimicking the action of prostaglandin I2, or PGI2, a naturally occurring compound in the body.
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...
465
Regulation of Angiogenesis and Blood Supply
3.3K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
3.3K

