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Updated: May 7, 2026

Preclinical Assessment of the Bioactivity of the Anticancer Coumarin OT48 by Spheroids, Colony Formation Assays, and Zebrafish Xenografts
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探索β-阿米林的抗癌潜力:可扩展的隔离过程,半合成和分子对接研究

Telukuntla Sai Priya1, Sonam Swain2, Banoth Venkateswara Rao1

  • 1Department of Natural Products and Medicinal Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India; Academy of Scientific and Innovative Research, (AcSIR), Ghaziabad 201002, India.

Bioorganic & medicinal chemistry
|September 16, 2025
PubMed
概括

研究人员合成了具有有前途的抗癌特性的新型β-amyrin衍生物. 这些化合物通过巴克斯蛋白通路有效诱导亡,显示出新癌症药物开发的潜力.

关键词:
阿尔斯托尼亚学士 (L.)停靠对接 停靠对接半合成 半合成这种类型的Triterpenoids.癌细胞 癌细胞 癌细胞这是一种β-Amyrin.

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Antifungal Agents01:15

Antifungal Agents

Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to...
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