生理和生物力学参数对肺变形的影响以及肺瘤运动估计的准确性
Hamid Ladjal1, Behzad Shariat1
1Université Claude Bernard Lyon 1, LIRIS CNRS - UMR 5205, 23-25 Av. Pierre de Coubertin, 69100, Villeurbanne, France.
Computers in biology and medicine
|September 16, 2025
概括
针对患者的生物机械模型改善了用于放射治疗的肺瘤运动预测. 非线性个性化肺部符合性和特定的超弹性模型 (Saint-Venant-Kirchhoff,Mooney-Rivlin) 提供更高的准确性,降低安全边际并保护健康的组织.
科学领域:
- 生物医学工程 生物医学工程
- 计算生物学 计算生物学
- 医学物理 医学物理
背景情况:
- 精确预测肺瘤位置对于有效的放射治疗至关重要.
- 为了改善这些预测,正在开发针对患者的呼吸系统生物机械模型.
- 模拟的准确性在很大程度上取决于机械行为和生理特性.
研究的目的:
- 研究机械和生理性质不确定性对肺瘤运动预测的影响.
- 为了比较线性与非线性肺部合规模型来计算肺部和隔膜应变.
- 为呼吸模拟确定最适合的超弹性机械模型.
主要方法:
- 开发了一种针对患者的呼吸系统生物机械模型.
- 评估了Young的模量和Poisson比率的变化.
- 比较线性和非线性肺部合规模型.
- 在公共数据集上使用Neo-Hooke,Yeoh,Mooney-Rivlin和St. Venant-Kirchhoff超弹性模型模拟呼吸运动.
主要成果:
- 与线性模型相比,非线性个性化肺部合规性显著提高了准确性.
- 的模量变化对结果的影响很小,而波桑的比率变化对结果的影响很大.
- 圣维纳特-基尔霍夫和穆尼-里夫林模型显示了最高的准确性,平均基准误差为2.1±1.3mm.
结论:
- 非线性个性化肺部遵从性提高了肺瘤运动预测的准确性.
- 圣维南特-基尔霍夫和穆尼-里夫林模型最适合用于呼吸模拟.
- 精确的瘤运动预测可以降低放射治疗的安全边缘,并尽量减少对健康组织的损伤.
相关概念视频
Assessment of Ventilation I: Respiratory Rate
Assessment of Ventilation
A Ventilation assessment is critical for monitoring a patient's health status. Respiration, one of the most accessible vital signs, provides insights into the function of numerous body systems and can indicate serious health issues, such as brainstem injuries from head trauma.
Critical Guidelines for Assessing Ventilation:
A Ventilation assessment is critical for monitoring a patient's health status. Respiration, one of the most accessible vital signs, provides insights into the function of numerous body systems and can indicate serious health issues, such as brainstem injuries from head trauma.
Critical Guidelines for Assessing Ventilation:
Respiratory Volumes
Respiratory volumes are crucial metrics, meticulously measured to quantify the air exchanged in and out of the lungs during various phases of the breathing cycle. These precise measurements are vital for assessing lung function, diagnosing respiratory conditions, and monitoring overall respiratory health. Each parameter provides specific insights into the mechanics of breathing and the functional capacity of the lungs.
Tidal Volume (TV) Tidal volume (TV) is the air inhaled or exhaled in a...
Tidal Volume (TV) Tidal volume (TV) is the air inhaled or exhaled in a...
Pressure Relationships in Thoracic Cavity
Breathing, otherwise known as pulmonary ventilation, is the process of air movement into and out of the lungs. The main mechanisms propelling pulmonary ventilation are atmospheric pressure (Patm), intra-pulmonary (Ppul ) or intra-alveolar pressure (Palv) within the alveoli, and intrapleural pressure (Pip) within the pleural cavity.
Breathing Mechanisms
Both intra-alveolar and intrapleural pressures rely on specific lung properties. The ability to breathe—allowing air to enter the lungs during...
Breathing Mechanisms
Both intra-alveolar and intrapleural pressures rely on specific lung properties. The ability to breathe—allowing air to enter the lungs during...
Factors Affecting Pulmonary Ventilation
Besides the pressure difference between the external environment and the lungs, the airflow rate and ease of pulmonary ventilation are also influenced by three other factors: surface tension of the fluid in the alveoli, compliance of the lungs, and airway resistance.
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
Physical Assessment of the Respiratory Tract II: Inspection
Physical assessment of the respiratory tract through inspection is a crucial step in understanding the patient's respiratory health. It provides insights into the functioning of the respiratory system, the musculoskeletal structure, and even the patient's nutritional status. This comprehensive approach involves observing several vital aspects: chest configuration, breathing patterns, respiratory rates, skin color, and use of accessory muscles.
Chest Configuration
The chest configuration can...
Chest Configuration
The chest configuration can...
Pulmonary Function Tests
Pulmonary Function Tests (PFTs)
Pulmonary Function Tests are crucial diagnostic tools for assessing respiratory function, particularly in patients with chronic respiratory disorders. They comprehensively evaluate lung volumes, ventilatory function, breathing mechanics, diffusion, and gas exchange. These tests help diagnose pulmonary diseases and play a significant role in monitoring disease progression, evaluating disability, and assessing response to therapy.
PFTs involve using a spirometer, a...
Pulmonary Function Tests are crucial diagnostic tools for assessing respiratory function, particularly in patients with chronic respiratory disorders. They comprehensively evaluate lung volumes, ventilatory function, breathing mechanics, diffusion, and gas exchange. These tests help diagnose pulmonary diseases and play a significant role in monitoring disease progression, evaluating disability, and assessing response to therapy.
PFTs involve using a spirometer, a...


