微塑料干扰肠道微生物群的定量评估:识别敏感指标和关键因素
Runqi Liu1, Zhanao Zhang1, Yan Zhang1
1State Key Laboratory of Water Pollution Control and Green Resource Recycling, School of Environment, Nanjing University, Nanjing, Jiangsu, 210023, China.
Environmental research
|September 16, 2025
概括
微塑料 (MP) 破坏肠道微生物群,但敏感指标尚不清楚. 这项研究发现,Firmicutes/Bacteroidetes比率是一个关键的生物标志物,MPs度,大小和持续时间会影响它.
科学领域:
- 环境科学 环境科学
- 微生物学 微生物学
- 毒理学 毒理学 毒理学
背景情况:
- 微塑料 (MP) 是普遍存在的污染物,在胃肠道中积累.
- 国会议员破坏肠道微生物群,但敏感指标和暴露因素仍然不清楚.
研究的目的:
- 开发一个数据驱动的框架,使用元分析和机器学习来评估MP对肠道微生物群的影响.
- 确定MPs诱导的肠道微生物群破坏的敏感生物标志物和关键暴露特征.
主要方法:
- 对MPs和肠道微生物群的文学数据的元分析.
- 机器学习模型用于定量评估的应用.
- 确定关键的暴露因素 (度,大小,持续时间) 和响应指标 (香农指数,细菌类,F/B比率).
主要成果:
- 香农指数,Firmicutes,Bacteroidetes,Actinobacteria的丰富度,以及Firmicutes/Bacteroidetes (F/B) 比率显著响应了MP的暴露.
- F/B比率成为国会议员干预的最敏感指标.
- 基于MP的暴露特征,开发了一种预测F/B比率变化的定量模型 (R2 = 0.91).
结论:
- F/B比为MPs诱导的肠道微生物群破坏的一个敏感生物标志物.
- MPs的度,大小和持续时间是影响F/B比率的关键因素.
- 这项研究为评估MP污染的胃肠道风险提供了洞察力和技术支持.
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