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微泡特性和载波频率对超声波化诱导的流量增强的影响
J Todd Belcik1, Aris Xie2, Yue Qie1
1Knight Cardiovascular Institute, Oregon Health and Science University, Portland, Oregon.
概括
微气泡 (MB) 腔化增强了组织输液,可变形性和超声频率显著影响了流量增大. MB充电没有影响 perfusion 的改善,突出了优化这种治疗方法的关键因素.
科学领域:
- 生物医学工程 生物医学工程
- 超声波技术 超声波技术 超声波技术
- 心血管研究研究心血管研究
背景情况:
- 微气泡 (MB) 化诱导血管扩张,并通过切割敏感通道增加组织 perfusion.
- 了解影响MB化效应的因素对于治疗应用至关重要.
研究的目的:
- 研究MB的变形性,电荷和超声波 (US) 频率如何影响化诱导的组织 perfusion.
- 确定MB特性和US参数在剪切介导血管扩张中的作用.
主要方法:
- 在小鼠体内研究,使用可变形和不太可变形的MBs,具有不同的电荷.
- 在MB给药期间低 (1.3MHz) 和高 (7.0MHz) 的US频率的比较.
- 量化对比增强的美国输液成像和腺三酸盐释放试验.
主要成果:
- 在1.3MHz的高度可变形的MBs增加了肢体 perfusion 6至8倍.
- 不太容易变形的MB显示流量增加减少 (4倍),而MB充电没有显著影响.
- 高频US (7.0 MHz) 显著降低了60-70%的流量增强响应.
结论:
- MB变形性和US频率是空腔介导流量增强的关键决定因素.
- 尽管存在潜在的内皮相互作用,但MB电荷不会影响 perfusion 增强的程度.
- 优化MB属性和US参数对于最大限度地提高MB化治疗效益至关重要.
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