在患双相情感障碍高风险的年轻人中异常的白质微观结构
Haoran Xu1, Lu Lu2, Corey R Jones3
1Department of Interventional Therapy, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; Department of Radiology, Huaxi MR Research Center (HMRRC), Institute of Radiology and Medical Imaging, Psychoradiology Key Laboratory of Sichuan Province, West China Hospital of Sichuan University, Chengdu, Sichuan, China; Research Unit of Psychoradiology, Chinese Academy of Medical Sciences, Chengdu, Sichuan, China; Department of Psychiatry, College of Medicine, University of Cincinnati, Cincinnati, Ohio.
患双相情感障碍 (BD) 高风险的青少年在关键脑道中表现出明显的白质异常. 这些发现表明,在风险青年早期干预的潜在结构性目标.
科学领域:
- 神经科学是一个神经科学.
- 神经成像是一种神经成像.
- 精神病学是一个精神病学.
背景情况:
- 双极性障碍 (BD) 与前额外边缘电路异常有关.
- 患有BD家族病史的年轻人可能会早期出现情绪症状,增加他们的风险.
- 了解青少年BD风险的机制至关重要.
研究的目的:
- 为了确定与健康对照组 (HC) 相比,高风险年轻人的白质连接性差异.
- 调查青少年BD风险增加的潜在结构性基础.
主要方法:
- 使用了扩散张力成像 (DTI) 和自动纤维量化.
- 在高危年轻人 (n=108) 和HC年轻人 (n=45) 中比较白质道的微观结构性质.
- 在高风险青年中检查了临床测量和扩散特性之间的相关性.
主要成果:
- 与HC相比,高风险的年轻人表现出与前丘脑辐射,皮质脊髓通道和小骨管相比,在前丘脑辐射,皮质脊髓通道和小骨管中呈现出改变的分数异构和扩散性.
- 在高风险年轻人中,微观结构指标和焦虑/全球功能尺度之间发现了显著的相关性.
结论:
- 患有BD风险的年轻人在关键区域显示出白质完整性的改变.
- 这些白质变化可能是风险青少年情绪失调的结构性基础.
- 识别这些变化为早期干预策略提供了潜在的目标.
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