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与IgG抗体相比,针对CD20的工程IgM抗体增强了补充依赖的细胞毒性

Kevin C Hart1, Paul R Hinton1, Marigold Manlusoc1

  • 1IGM Biosciences Inc., 325 E Middlefield Rd., Mountain View, CA.

Experimental hematology
|September 16, 2025
PubMed
概括

与用于B细胞淋巴瘤治疗的IgG抗体相比,抗CD20IgM抗体显示出优异的补充依赖性细胞毒性 (CDC). 这种IgM抗体对抗抗性癌细胞具有更强的疗效,这表明它是一个有前途的治疗替代方案.

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Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
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