验证转换的临床实践研究数据链接 (CPRD) 黄金和光的数据进入OMOP常用数据模型
George Kafatos1, Joe Maskell1, Olia Archangelidi1
1Center for Observational Research, Amgen Ltd, Uxbridge, UK.
Health informatics journal
|September 16, 2025
概括
英国临床实践研究数据链 (CPRD) 数据库的转换为观察医学结果伙伴关系 (OMOP) 共同数据模型 (CDM) 是一致的. 使用OMOP转换的CPRD数据进行的分析可以信任,观察到的差异最小.
科学领域:
- 医疗信息学 医疗信息学
- 观察性健康数据分析
- 临床数据标准化标准化
背景情况:
- 临床实践研究数据链 (CPRD) 是英国一个有价值的现实世界健康数据库.
- 将数据标准化为观察医学结果伙伴关系 (OMOP) 共同数据模型 (CDM) 便于多数据库研究.
- 评估数据转换的准确性对于可靠的现实世界证据生成至关重要.
研究的目的:
- 评估将英国CPRD数据库转换为OMOP CDM版本 5.3.1.1. 的准确性和一致性.
- 为了量化临床事件计数在源CPRD数据库和其OMOPCDM对应数据库之间的差异.
- 为研究使用OMOP转换的CPRD数据提供信心.
主要方法:
- 系统生成医疗代码列表用于绘制地图.
- 在源 CPRD (GOLD 和 Aurum) 和 OMOP CDM 版本之间比较流行和事件临床事件计数.
- 对不同OMOP CDM表中的代码映射所导致的差异分析.
主要成果:
- 对于CPRD GOLD,89.5%的临床事件在转化后的计数中没有或只有很小的差异.
- 对于CPRD Aurum,97.4%的事件显示没有或数量差异很小.
- 观察到的差异通常与OMOP CDM表中的特定代码映射有关.
结论:
- 对于CPRD数据库的OMOP转换过程显示出高度的一致性.
- 这些发现支持使用OMOP转换的CPRD数据用于分析目的的可靠性.
- 对使用OMOP-CDM格式化的CPRD数据的研究人员建立了信心.
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