识别Mi2的肌肉炎特异性自身抗体也针对在共享PHD指的AIRE蛋白

Jon Musai1, Sahana Jayaraman2, Katherine Pak1

  • 1Muscle Disease Section, National Institute of Arthritis and Musculoskeletal and Skin Disease, National Institutes of Health, Bethesda, Maryland, USA.

PubMed
概括

在皮肤肌炎中针对Mi2的自身抗体也通过共享的PHD1表位素识别AIRE. 这表明一种机制,即抗Mi2自身抗体通过干扰Mi2/NuRD复合体和其他含有PHD1的蛋白质来破坏染色质结合.

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