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在ABO不兼容移植手术并发症:一个单一中心的经验
Ahmed M Abdel Gawad1, Abhijit Patil2, Abhishek Singh2
1Urology Department, Muljibhai Patel Urological Hospital, Nadiad, Gujarat, India; Urology Department, Faculty of Medicine, Al-Azhar University, New Damietta, Egypt.
Transplantation proceedings
|September 16, 2025
概括
与ABO不相容的移植 (ABOi-KT) 为供体短缺提供了可行的解决方案,实现了高的移植和患者存活率. 然而,管理排斥和并发症需要改进移植前和移植后的策略.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 移植免疫学 移植免疫学
- 外科手术的结果
背景情况:
- 由于ABO兼容的活捐赠者的严重短缺,需要采用替代策略,例如ABO不兼容的移植 (ABOi-KT).
- 我们的中心自2012年以来一直积极进行ABOi-KT,为这个程序的越来越多的证据提供了贡献.
研究的目的:
- 评估ABOi-KT的有效性和短期结果.
- 确定手术并发症的预测因素,并评估患者和移植的存活率.
主要方法:
- 来自123个ABOi-KT程序 (2012-2021) 的前性维护数据的回顾性分析.
- 主要结局包括术前结果,初级功能移植 (PFG),活检证明的急性排斥 (BPAR) 和1年生存率.
- 二次结果集中在手术并发症及其预测因素上.
主要成果:
- 高 PFG 率 (98.4%) 和 1 年移植存活率 (87%).
- 20%的患者出现了BPAR;患者1年生存率为99%.
- 手术并发症 (31.7%,主要是感染) 和BPAR显著影响了移植的存活率;增加了预测的等离子体变异并发症.
结论:
- ABOi-KT 是克服供体短缺的一个可行的选择,证明了可接受的患者和移植存活率.
- 排斥率和并发症的增加强调了需要优化预调和移植后管理协议的必要性.
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