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Updated: Jan 17, 2026

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
07:41

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators

Published on: February 20, 2018

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机器学习导航了Allosteric网络,揭示了GPCRs偏差的Allosteric调制

Ming Kong1, Xin Chen1, Jun Mao1

  • 1College of Chemistry, Sichuan University, Chengdu 610064, China.

Journal of chemical theory and computation
|September 16, 2025
PubMed
概括

我们开发了一种机器学习策略,以了解G蛋白结合受体 (GPCRs) 的偏向性全调节器 (BAMs). 这种方法阐明了SBI-553药物如何调节NTSR1,为更安全的GPCR疗法提供了洞察力.

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Allosteric Regulation01:08

Allosteric Regulation

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Allosteric Proteins-ATCase

Binding sites linkages can regulate a protein's function.  For example, enzyme activity is often regulated through a feedback mechanism where the end product of the biochemical process serves as an inhibitor.
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