长期COVID和月经之间的潜在双向关系
Jacqueline A Maybin1, Catherine Walker2, Marianne Watters2
1Centre for Reproductive Health, University of Edinburgh, Edinburgh, UK. jackie.maybin@ed.ac.uk.
Nature communications
|September 16, 2025
概括
长期的COVID与异常的子宫出血 (AUB) 和月经症状增加有关. 症状的严重程度在月经周期内波动,可能是由于炎症而不是荷尔蒙失衡.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
背景情况:
- 在SARS-CoV-2感染后报告的月经变化和周期性症状变化.
- 需要调查COVID-19,长期COVID和月经健康之间的联系.
研究的目的:
- 评估COVID-19与异常子宫出血 (AUB) 的关联.
- 确定长期COVID症状是否在月经周期之间有所不同.
- 探索潜在的潜在机制.
主要方法:
- 英国人口研究比较了长期COVID,急性COVID和从未感染过的群体的月经出血模式.
- 在54名女性的月经周期阶段中分析长期COVID症状严重程度.
- 对激素和炎症标记物的血清和子宫内膜组织分析.
主要成果:
- 与未感染的个人相比,长期COVID与月经量,持续时间和月经间出血增加有关.
- 急性COVID恢复显示了最小的月经干扰.
- 长期COVID症状在经期前期和生殖期达到顶峰.
- 在长期COVID中,血清5α-dihydrotestosterone升高和子宫内膜雄激素受体降低.
- 在子宫内膜中增加月经炎症和免疫细胞聚集.
结论:
- 长期COVID与AUB有关,但不会影响卵巢功能.
- 周围和子宫内膜炎症可能导致AUB和长期COVID症状严重程度.
- 这些发现可能会为长期COVID的妇女提供新的治疗策略.
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