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Updated: Jan 17, 2026

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通过PLK1介导的PDHA1酸化驱动了肺癌中的代谢重编程

Jia Peng1, Qiongsi Zhang1, Xiongjian Rao1

  • 1Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, KY, USA.

Oncogene
|September 16, 2025
PubMed
概括

波罗样类激酶1 (PLK1) 通过酸化PDHA1驱动癌症中的代谢重编程,将细胞从氧化酸化转移到糖解. 这种机制为肺癌治疗提供了新的治疗点.

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