诊断时的颗粒细胞丰度和成熟状态预测CML的无治疗缓解
Mikko Purhonen1,2,3, Mikael Tatun1,2,3, Katariina Luukkainen1,2,3
1Hematoscope Lab, Comprehensive Cancer Center, Helsinki University Hospital, Helsinki, Finland.
Leukemia
|September 16, 2025
概括
骨髓细胞形态学可以预测慢性髓性白血病 (CML) 的无治疗缓解期 (TFR). 诊断时的颗粒细胞扩张和成熟与持续的TFR有关,提供了潜在的可访问生物标志物.
科学领域:
- 血液学 血液学 血液学
- 计算病理学计算病理学
- 在瘤学瘤学.
背景情况:
- 无治疗缓解 (TFR) 是慢性阶段慢性髓性白血病 (CP CML) 的一个关键目标.
- 目前,没有标准化生物标志物可靠地预测TFR成功.
- 骨髓 (BM) 细胞形态学是全球可访问的,是诊断的组成部分.
研究的目的:
- 研究骨髓细胞形态学的潜力,作为CPCML中TFR的预测生物标志物.
- 探索BM细胞形态学的基于深度学习的图像分析的实用性.
主要方法:
- 多中心研究包括113名试图停止TKI治疗的CP CML患者.
- 数字化和深度学习分析诊断BM吸入图像.
- 与942个对照BM样本进行比较,以确定细胞形态学概况.
主要成果:
- 在CP CML患者中确定了一个独特的BM细胞形态指纹.
- 发现了与持续的TFR相关的中性粒细胞丰度和颗粒细胞成熟.
- 视觉证实了这些发现,并证明了它们与已知的临床因素的独立性.
结论:
- 计算性BM细胞形态学显示出确定TFR的新型临床生物标志物的前景.
- 诊断时的颗粒细胞扩张和成熟可能表明影响TFR维持的内在疾病特征.
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