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Updated: Jan 17, 2026

Assessing Cellular Target Engagement by SHP2 PTPN11 Phosphatase Inhibitors
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酸酶PTPN22在mTORC2复合体中起到适配器的作用

Keshav Gupta1,2, Nagalakshmi Kommineni1, Tanuja Bogadi1

  • 1Laboratory of Cell Death & Cell Survival, Centre for DNA Fingerprinting and Diagnostics (CDFD), Uppal, Hyderabad, Telangana, 500039, India.

EMBO reports
|September 16, 2025
PubMed
概括

氨酸酸酶PTPN22作为支架蛋白,对于mTORC2复合体组装和AKT通路激活至关重要. 这种PTPN22的非催化作用对于细胞生长和存活至关重要.

关键词:
在 AKT AKT 里面.在PTPN2222中使用.里克托尔·里克托尔 (Rictor Rictor) 是一个著名的艺术家.mSIN 的意思是在mTOROR中使用mTOR.

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