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普里斯蒂纳辛-抗生素组合治疗从皮肤感染中恢复的抗甲素耐药黄金葡萄球菌
Muath Suliman1, Amr S Bishr2, Sally T K Tohamy3
1Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, P.O. Box 61413, 9088, Abha, Saudi Arabia.
在埃及的皮肤感染中,抗麦克罗利德和抗甲素的金黄色葡萄球菌很普遍. 普里斯胺素与多西环素或勒沃素结合显示出协同效应,提供了潜在的新疗法.
科学领域:
- 临床微生物学 临床微生物学
- 传染性疾病 传染性疾病
- 抗微生物耐药性 抗微生物耐药性
背景情况:
- 由于治疗选择有限,对宏胺耐药和甲素耐药黄金葡萄球菌 (MRSA) 构成重大挑战.
- 在MRSA中抗胺素的耐药性进一步复杂化了管理,需要研究有效的治疗策略.
研究的目的:
- 确定埃及一家主要的三级医疗医院中抗宏化物和甲素的黄金色细菌的流行率.
- 评估这些耐药分离物的抗微生物敏感性模式.
- 为了评估各种普里斯胺素 (PST) - 抗生素组合的疗效.
主要方法:
- 隔离,识别和S. aureus从皮肤感染中抗菌敏感性测试.
- 对关键的类和甲素抗性基因 (mecA, ermC, ermA, msrA) 的分子分析.
- 对PST与抗生素组合的表型相关性和协同效应进行克板测定和热图分析.
主要成果:
- 在154个金黄色细菌分离物中,43%是多药耐药 (MDR).
- MDR分离体对素 (MRSA),红色素和澄素 (McRSA) 呈现高耐药性,对克林达米辛,阿齐素和PST具有显著的耐药性.
- 普里斯胺素-多西环素 (82.13%) 和普里斯胺素-莱沃弗洛克萨辛 (70.14%) 的组合显示出主要是协同效应.
结论:
- 皮肤感染中MRSA的高患病率强调了需要有效治疗的需要.
- 莱涅佐利德,万科米辛,提科普拉宁,普里斯蒂纳米辛,氨基醇和多克西环素仍然是可行的治疗选择.
- 普里斯蒂纳辛与多克西环素或勒沃素结合显示出对MDR S. aureus的临床评估有希望.
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