相关实验视频
Updated: Jan 17, 2026

07:37
An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
Published on: June 6, 2025
1.0K
基因预测的免疫细胞和代谢物调解炎症因素和类风湿性关节炎之间的因果关系
Tianyang Li1, Jinpeng Wei, Hua Wu
1Department of Orthopedics, Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, China.
Medicine
|September 17, 2025
概括
这项研究揭示了CD40L受体 (一种炎症因素) 与类风湿性关节炎 (RA) 之间的因果关系. 特定的免疫细胞和代谢物调解这种关系,为RA的发病过程提供了新的见解.
科学领域:
- 免疫学 免疫学 免疫学
- 遗传学 是一个遗传学.
- 类风湿病学 类风湿病学
背景情况:
- 类风湿性关节炎 (RA) 是一种具有复杂病因的慢性自身免疫性疾病.
- 炎症因素与RA的发病有关,但因果关系和介导途径仍然不完全理解.
研究的目的:
- 使用孟德尔随机化研究炎症因素和类风湿性关节炎 (RA) 之间的因果关系.
- 确定潜在的免疫细胞和代谢物,这些代谢物调解炎症因素对RA的影响.
- 量化由已识别的免疫细胞和代谢产物介导的总效应的比例.
主要方法:
- 采用双向的门德尔随机化研究设计.
- 使用了全基因组关联研究 (GWAS) 总结统计数据.
- 进行中介分析以评估间接影响和估计中介比例.
主要成果:
- 升高的CD40L受体水平与RA风险增加有因果关系.
- 通过CD14+CD16-单细胞百分比 (1.89%介导) 观察到CD40L受体对RA的间接影响.
- 代谢物X-24757 (10.6%介导) 和IgD在IgD+CD38-未切换的记忆细胞 (11.6%介导) 上也表现出介导作用.
结论:
- 在炎症因子CD40L受体和类风湿性关节炎之间存在因果关系.
- 特定的免疫细胞群 (单细胞,未切换的记忆B细胞) 和代谢物 (X-24757) 调解CD40L受体和RA之间的关系.
- 这些发现突出了RA干预的潜在治疗目标.
相关概念视频
T Cell Types and Functions
2.2K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
2.2K
Autoimmune Disorders
1.5K
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
Concept and Mechanism of Autoimmune Diseases
The immune...
1.5K
Inflammatory Response
16.0K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
16.0K
The JAK-STAT Signaling Pathway
12.1K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
12.1K
Genome-wide Association Studies-GWAS
15.3K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
15.3K

