腺体缩和喉回流之间的双向风险关联:一个系统的元分析
Chaofan Li1, Juan Ye1, Shaokun Huang1
1Qinghai University Medical College, Xining, Qinghai, People's Republic of China.
Medicine
|September 17, 2025
概括
腺体缩 (AH) 和喉回流 (LPR) 在儿童中密切相关. 这次元分析发现,LPR在患有AH的儿童中更为普遍,这表明存在显著的关联.
科学领域:
- 儿科耳鼻喉科 儿科耳鼻喉科
- 胃肠病学 胃肠病学
背景情况:
- 腺体缩 (AH) 和喉回流 (LPR) 是常见的儿科疾病,病理联系不清楚.
- 了解AH和LPR之间的关系对于有效的儿科耳鼻喉和胃肠道管理至关重要.
研究的目的:
- 在儿科患者群体中探索腺体缩和喉回流之间的关联.
- 调查潜在的因果关系和机械基础,将AH和LPR联系在一起.
主要方法:
- 一个系统的文献综述和18项研究的元分析 (3个横截面,15个队列) 涉及39427名参与者.
- 在PubMed,Web of Science和Cochrane图书馆数据库中进行了文献选.
- 方法质量使用纽卡斯尔-太华尺度和跨部门研究评估工具进行评估;使用道图形分析出版偏差.
主要成果:
- 分析显示,AH儿童的LPR风险显著增加 (OR = 10.53).
- 经过多次腺切除术 (AT) 的儿童患上LPR的风险增加 (RR = 9.43).
- 虽然AT缓解了短期LPR症状 (<1年),但长期随访 (>10年) 表明LPR易感性增加 (RR = 2.03),这表明相互关系.
结论:
- 这项研究初步验证了小儿病患者群体中AH和LPR之间的密切关联.
- 这些发现表明,LPR可能在AH的发展和进展中发挥作用.
- 需要使用标准化诊断标准进行进一步的研究,以充分阐明AH和LPR之间的相互关系,这是由于先前研究中的异质性.
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