相关实验视频
Updated: Jan 17, 2026

06:58
Frailty Assessment in an Aging Mouse Model
Published on: September 23, 2025
436
肺功能和脆弱性:剂量反应关系,调解效应和预测模型
Sirui Zhou1,2, Ping Wang1, Weijian Zhu3
1Department of Respiration, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China.
Medicine
|September 17, 2025
概括
肺功能下降,以预测峰值呼气流量 (PEFpred%) 的百分比来衡量,与中国老年人的脆弱性风险更高有关. 认知功能部分调解了这种关联,为早期查和干预策略提供了信息.
科学领域:
- 老年学与公共卫生
- 呼吸系统医学 呼吸系统医学
- 认知科学 认知科学
背景情况:
- 肺功能,认知能力和生活方式对于老年人的健康和脆弱性预测至关重要.
- 在中国人群中,肺功能和虚弱之间的联系尚不清楚.
- 现有的临床脆弱性评估缺乏标准化.
研究的目的:
- 利用肺功能,认知能力和生活方式因素开发一种脆弱风险预测模型.
- 为中国中老年人和老年人的早期脆弱查和干预提供基础.
主要方法:
- 利用来自中国健康与退休长度研究的6065名中国成年人 (≥45岁) 的数据.
- 测量的峰值呼气流量 (PEF) 和预测PEF的计算百分比 (PEFpred%).
- 采用多层逻辑回归,引导方法,LASSO回归和交叉验证用于分析和模型开发.
主要成果:
- 较高的PEFpred%与较低的骨折风险显著相关,具有非线性剂量-反应关系.
- 认知功能部分介导了PEF前期%和脆弱性之间的关系,占影响的20.11%.
- 开发的脆弱性风险预测模型表现良好 (AUC 0.796培训,0.775验证).
结论:
- 预测的峰值呼气流 (PEFpred%) 的百分比是中国中年和老年人群中虚弱风险的有价值的预测指标.
- 认知功能在肺功能和脆弱性之间的关联中发挥着重要的调解作用.
- 开发的预测模型显示了早期脆弱性检测和管理中的临床应用的前景.
相关概念视频
Drug Dosing: Geriatric Patients
228
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
228
Dose-Response Relationship: Overview
4.9K
Agonists can bind with and activate receptors, resulting in the formation of drug-receptor complexes. Once formed, these complexes catalyze many biochemical processes at the cellular level and subsequently induce a pharmacologic response. The degree of response is directly proportional to the fraction of activated receptors, which in turn, depends on the concentration of the drug at the receptor site as well as the sensitivity of the receptor. An increase in the administered dose contributes to...
4.9K
Dose-Response Relationship: Potency and Efficacy
6.4K
The potency of a drug is the measure of its ability to produce a biological response and can be compared by looking at the half-maximum effective concentration or EC50 values of different drugs. A lower EC50 value indicates higher potency of the drug. In the dose–response curve of two antihypertensive drugs, candesartan and irbesartan, a significant difference is observed in their EC50 values. A lower EC50 value for candesartan indicates that it is more potent than irbesartan, as it...
6.4K
Renal Failure: Dose Adjustments
438
In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
438
Pharmacodynamics in Geriatric Patients: Effects of Age
188
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
188
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion
238
In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
238

