咖啡摄入量与骨健康之间的因果关系:孟德尔的随机化研究
Heng Yang1, Liling Yang2, Zongping Li3
1Department of Orthopaedics, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, Sichuan, PR China.
Medicine
|September 17, 2025
概括
这项研究发现,咖啡消费与骨关节炎,类风湿性关节炎或骨质疏松症风险之间没有因果关系. 门德尔随机分析证实,咖啡摄入量不会影响这些骨和关节疾病的发展.
科学领域:
- 遗传学 遗传学 是一个
- 流行病学 流行病学
- 类风湿病学 类风湿病学
背景情况:
- 观察性研究表明,咖啡摄入量与骨关节炎 (OA),类风湿性关节炎 (RA) 和骨质疏松症 (OP) 之间存在关联.
- 这些观察到的关联的因果关系尚不清楚.
研究的目的:
- 调查咖啡摄入量与OA,RA和OP风险之间的潜在因果关系.
- 使用一个强大的双向双样本的门德尔随机化 (MR) 方法.
主要方法:
- 进行了两样双向门德尔随机化 (MR) 分析.
- 包括英国生物库参与者在内的大型基因组广泛关联研究 (GWAS) 的遗传数据用于OA,RA,OP和咖啡摄入量.
- 使用逆方差加权 (IVW),MR-Egger和加权中位数方法,通过Cochran的Q统计和SNP选择的MR-PRESSO评估异质性.
主要成果:
- 没有证据表明咖啡摄入量与RA风险之间存在因果关系 (OR:0.84;95%CI:0.24-2.93).
- 对咖啡摄入的遗传倾向与OA (OR: 1.21;95% CI: 1.01-1.45) 或OP (OR: 1;95% CI: 0.99-1.0) 并没有显著相关.
- 反向MR分析也显示OA,RA或OP对咖啡摄入量没有显著的因果关系.
结论:
- 这些发现不支持咖啡消费与患骨关节炎,类风湿性关节炎或骨质疏松症的风险之间的因果关系.
- 这项研究提供了强有力的证据,反对咖啡摄入量在这些普遍的肌肉骨疾病中起因作用.
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