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Updated: Jan 17, 2026

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MVSL-DSF:多视图子空间表示学习和跨模态特征动态聚合,用于增强药物副作用频率预测
Mao Liu1, Xiangmin Ji1,2, Yan Ren1,2
1School of Automation and Electrical Engineering, Inner Mongolia University of Science and Technology, Baotou 014010, China.
Journal of chemical information and modeling
|September 17, 2025
概括
这项研究引入了一种新的多视图子空间学习方法 (MVSL-DSF),以准确预测药物副作用频率. 该方法通过整合各种数据来改善药物安全性,从而改善药物风险评估和药物监管.
科学领域:
- 药监和药物安全 药监和药物安全
- 计算药理学计算药理学
- 医疗保健中的机器学习
背景情况:
- 药物的副作用对发病率和死亡率有很大影响.
- 准确评估药物的副作用频率对于药物开发和风险分析至关重要.
- 目前的方法经常使用单视图图神经网络,限制了使用药物间和副作用间信息和多变量数据特征的使用.
研究的目的:
- 提出一种新的多视图子空间表示学习聚合方法 (MVSL-DSF),用于预测药物副作用频率.
- 通过整合来自各种药理网络的多变量数据特征来克服现有方法的局限性.
- 通过精确量化药物副作用频率,加强药物风险评估和药物监督.
主要方法:
- 开发了MVSL-DSF,一种将药物,副作用和相互作用视图映射到共享的低维空间的方法.
- 采用堪培拉远程驱动的跨模式关注,以优化多视图的一致性和互补性.
- 稀少聚合特征,同时消除冗余信息,以增强模型的区分能力.
主要成果:
- 在基线实验中,MVSL-DSF实现了0.297的优化根平均平方误差 (RMSE) 和0.167的平均绝对误差 (MAE).
- 与现有最先进的方法相比,表现出优越的性能.
- 构建了一个频率-严重性矩阵来预测药物风险水平.
结论:
- 多视图建模使药物副作用频率从多源数据精确量化.
- 拟议的MVSL-DSF方法增强了特征的表示,差异化和互补性.
- 研究结果支持改善风险评估,临床决策,药物安全和药物监督.
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