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系统性炎症是体重调整的腰部指数和高血压之间的缺失环节吗? 来自NHANES研究的结果

Lijing Yang¹, Yi Hu², Siyu Chen¹

¹Department of Clinical Laboratory, The First People's Hospital of Shuangliu District, Chengdu/West China (Airport) Hospital, Sichuan University, Chengdu, China.

|September 17, 2025

概括

体重调整后的腰部指数 (WWI) 与高血压风险有关,特别是当WWI为11.70或以下时. 系统性炎症在这种与肥胖相关的高血压连接中起着部分作用.

科学领域:

心脏病学心脏病学
代谢健康代谢健康
肥胖问题研究研究

背景情况:

体重调整腰部指数 (WWI) 是一种新兴的肥胖指标.
它与高血压 (HTN) 的联系和炎症的作用尚未完全理解.

研究的目的:

调查第一次世界大战和HTN之间的关联.
为了探索系统性炎症标记物的调解作用:C-反应蛋白-白蛋白-淋巴细胞比率 (CALLY),C-反应蛋白-白蛋白比率 (CAR) 和淋巴细胞-C-反应蛋白比率 (LCR).

主要方法:

对10869名美国成年人的数据进行分析 (NHANES 1999-2010).
使用多变量回归,受限立方线 (RCS) 和通用添加模型 (GAM).
通过引导式分析评估的调解效应.

主要成果:

较高的WWI与增加的HTN风险有很强的相关性 (OR=1.79).
最高的第一次世界大战四分位数与最低的四分位数相比 (OR=3.79) 的风险几乎增加了四倍.
炎症标志物CALLY,LCR和CAR部分介导了第一次世界大战-HTN的联系,单独解释了高达15.89%和13.91%的结合. 观察到一个非线性关联,在第一次世界大战的值 = 11.70.

结论:

WWI是高血压风险的独立,非线性预测指标,特别是在WWI ≤11.70.
系统性炎症部分介导了第一次世界大战和高血压之间的关系.
研究结果强调了炎症在与肥胖相关的高血压中的作用.

关键词:

尼汉斯 (NHANES) 是一个名人.体重调整的腰围指数这种高血压,高血压.这是一种炎症炎症炎症炎症.调解调解是一种调解方式.

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