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Updated: Jan 17, 2026

SorLA and CLC:CLF-1-dependent Downregulation of CNTFRα as Demonstrated by Western Blotting, Inhibition of Lysosomal Enzymes, and Immunocytochemistry
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SorLA and CLC:CLF-1-dependent Downregulation of CNTFRα as Demonstrated by Western Blotting, Inhibition of Lysosomal Enzymes, and Immunocytochemistry

Published on: January 6, 2017

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3-CaN-Smurf1复合物扣留FLCN-FNIPs,以促进TFEB激活,以应对内膜损伤

Qin Xia1, Ziwan Liu1, Gaoqing Feng1

  • 1State Key Laboratory of Hearing and Balance Science and Key Laboratory of Molecular Medicine and Biological Diagnosis and Treatment (Ministry of Industry and Information Technology), Aerospace Center Hospital, Advanced Technology Research Institute, Tangshan Research Institute, School of Life Science, Beijing Institute of Technology, Beijing, 100081, China.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|September 17, 2025
PubMed
概括

通过溶酶体损伤激活Smurf1会破坏FLCN-FNIP复合体,损害mTOR介导的TFEB酸化,并促进TFEB激活细胞平衡. 这揭示了癌症的新型治疗点.

关键词:
在FLCN-FNIP中.3 - N - 1复合体美国联邦税务法 (TFEB)损害了内膜的内膜损伤.lysosomal 应激症 发生在 lysosomal 应激症中.无处不在的无处不在关系

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The Cell-based L-Glutathione Protection Assays to Study Endocytosis and Recycling of Plasma Membrane Proteins09:22

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