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Updated: May 10, 2026

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人类天体细胞能量代谢的APOE基因型依赖差异

Vanessa Budny1,2, Chantal Bodenmann1, Kathrin J Zürcher1

  • 1Institute for Regenerative Medicine, University of Zurich, Schlieren, Switzerland.

Frontiers in cellular neuroscience
|September 17, 2025
PubMed
概括

阿波利波蛋白E4 (APOE4) 基因对天体细胞的能量代谢产生影响,增加阿尔茨海默病的风险. 与APOE2或APOE3.3不同的是,APOE4天体细胞显示出改变的糖解和线粒体呼吸.

关键词:
阿尔茨海默氏症 (AD) 是一种疾病.阿波利波蛋白E (APOE) 是一种能量代谢 能量代谢葡萄糖溶解是什么人类的星球细胞.诱导多能干细胞 (iPSCs) 是一种线粒体功能 线粒体功能线粒体脱离离合的过程

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