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与低骨质相关的肠道微生物群-代谢重塑:在骨折患者中进行的一项综合多omics研究
Xian Zhao1, Bin Wu2, Pengli Han3
1Peking University Fourth School of Clinical Medicine, Beijing, China.
Frontiers in molecular biosciences
|September 17, 2025
概括
骨折患者的低骨质量显示肠道微生物和代谢物的改变. 值得注意的是,Lachnospira eligens被丰富,而有益的细菌被耗尽,这表明了新的肠-骨轴洞察力.
科学领域:
- 微生物组研究的研究.
- 骨的新陈代谢 骨的新陈代谢
- 代谢学 代谢学 代谢学
背景情况:
- 骨质疏松症的发病与肠道微生物群有关,但其在骨折患者中的作用尚不清楚.
- 高分辨率的多omics研究对于理解微生物-代谢物-骨相互作用至关重要.
- 这项研究研究了低骨质骨折患者的肠道微生物和代谢特征.
研究的目的:
- 在骨折患者中具有低骨质量的肠道微生物和便代谢资料的特征.
- 为了确定与骨密度降低相关的特定细菌种群和代谢物.
- 在骨脆弱的背景下探索肠骨轴.
主要方法:
- 51名骨折患者的横截面研究,按骨矿物质密度分类.
- 在便样本上进行枪支元基因组测序和代谢学.
- 综合生物信息学分析以确定差异性种群,代谢物和相关性.
主要成果:
- 低骨质量 (LBM) 患者表现出明显的肠道微生物和代谢特征.
- *Lachnospira eligens*在LBM患者中被丰富,与其与肠道健康的通常关联相反.
- 有益的细菌 (*Bifidobacterium*, *Bacteroides stercoris*) 被消耗;确定了127种差异性代谢物,包括与炎症相关的与L. eligens*相关的代谢物.
- 使用四种细菌物种的诊断模型在LBM歧视方面获得了AUC>0.9.
结论:
- 骨折患者的低骨质量显示肠道微生物群-代谢轴重塑.
- 这项研究表明,L. eligens在低骨质中具有上下文依赖的,潜在的病理作用.
- 已识别的微生物和代谢特征为骨健康评估提供了机械洞察力和潜在的非侵入性生物标志物.
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