治疗I型胃神经内分泌瘤:越少越好?
Roberta Elisa Rossi1,2, Benedetta Masoni1,2, Valeria Poletti1,2
1Gastroenterology and Endoscopy Unit, IRCCS Humanitas Research Hospital, Milan, Italy.
Frontiers in endocrinology
|September 17, 2025
概括
一类胃神经内分泌瘤 (gNETs) 表现出惰的行为,大多数病变是通过内镜进行管理的. 由于局部复发可能发生,仔细监测至关重要,尽管转移和死亡很少发生.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 内分泌学 在内分泌学.
背景情况:
- 一类胃神经内分泌瘤 (gNETs) 的特点是预后普遍有利.
- 在临床实践中,关于I型gNETs管理和结果的现实数据对临床实践非常有价值.
研究的目的:
- 在第三级推中心介绍与I型gNETs的临床经验.
- 分析这些瘤的管理策略和结果.
主要方法:
- 在2014年至2024年期间,对被诊断患有I型gNET的患者进行了回顾性分析.
- 对瘤特征,治疗方法 (内镜切除,手术) 和随访数据的审查.
主要成果:
- 分析了23名患者的36个病变,中位数大小为7毫米. 大多数病变是G1 (29/36).
- 进行了34个病变的内镜切除;手术保留了一个G1和一个G2病变的特定指示.
- 在10个病变 (6名患者) 中观察到局部复发,所有病变都是G1和小 (中位数为3毫米). 没有发生转移或与瘤相关的死亡.
结论:
- I型gNETs表现出惰的行为,在大多数情况下支持内镜管理.
- 在一例中,术前内镜超声波 (EUS) 的分期影响了管理,突出了其潜在的作用.
- 需要进一步的研究来确定风险分层和最佳管理计划的预测因素.
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