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较大的中心肥胖与较差的左心室功能有关:社区动脉样硬化风险 (ARIC) 研究

Jorge L Reyes¹, Joseph J Decker¹, Romil Parikh²

¹Lillehei Heart Institute and Cardiovascular Division, Department of Medicine, University of Minnesota, Minneapolis.

Mayo Clinic proceedings. Innovations, quality & outcomes

|September 17, 2025

概括

中部脂肪的恶化,包括腰围和BMI,与随着时间的推移减少左心房功能有关. 保持健康的体重可能有助于预防心房肌病.

科学领域:

心脏病学心脏病学
公共卫生公共卫生
老年学是指老年学的学科.

背景情况:

通过腰围 (WC),腰比 (WHR) 和体重指数 (BMI) 来衡量的中心脂肪是越来越严重的公共卫生问题.
左心房 (LA) 功能对心脏健康至关重要,并且越来越被认为是心血管疾病的早期指标.
了解肥胖对LA功能的纵向影响对于制定预防策略至关重要.

研究的目的:

研究 WC,WHR,BMI 和 LA 功能的随时间变化之间的关联.
为了确定脂肪度测量的纵向变化是否与LA储,导管或收缩功能受损有关.

主要方法:

社区动脉样硬化风险研究的4008名参与者的分析与心声学LA菌株数据.
脂肪度量 (WC,WHR,BMI) 在两个时间点 (V4和V5) 进行评估,并根据变化进行分类 (持续低,持续高,增加,减少).
多变量线性回归模型根据心血管风险因素,体力活动和左心室 (LV) 大小和功能进行调整.

主要成果:

与持续较低的WC相比,持续升高的WC与明显较差的LA水库和管道功能有关.
增加WC和持续升高的WC与减少LA水库和管道功能有关.
持续升高的WHR与较差的LA储和导管功能有显著的关联.
持续升高的BMI与明显降低的LA储功能有关.
在WC,WHR或BMI和LA收缩功能变化之间没有发现显著的关联.

结论:

从中年到晚年,中部脂肪的恶化独立地与减少的LA储和导管功能有关.
这些发现凸显了维持健康的脂肪概况在一生中的重要性,以保持LA功能.
持续低脂肪可能在预防心房肌病症中发挥关键作用.

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