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个性化免疫疗法策略通过甲状腺癌的单细胞分析得到信息:一篇小小的综述
Ruyu Chen1, Zhimin Wang2, Xueying Chen2
1First Clinical College, Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, China.
Frontiers in immunology
|September 17, 2025
概括
单细胞分析揭示了多种类型的甲状腺癌 (TC) 亚型和免疫微环境,指导新的免疫疗法. 整合单细胞生物学的个性化策略可为耐火TC变体带来更好的结果.
科学领域:
- 单细胞生物学和免疫学
- 内分泌瘤学内分泌瘤学
- 癌症基因组学和转录基因组学
背景情况:
- 甲状腺癌 (TC) 在攻击性亚型的治疗进展有限.
- 对TC的免疫疗法正在通过单细胞分析进行演变.
- 了解瘤免疫相互作用对于治疗耐药性至关重要.
研究的目的:
- 在TC中剖析瘤和免疫细胞转录组.
- 识别影响治疗反应的细胞表型和免疫.
- 探索针对TC的新型免疫治疗策略.
主要方法:
- 超过15万个瘤和免疫细胞的单细胞RNA测序.
- 空间转录学和CITE-seq用于详细的细胞和分子分析.
- 功能性研究以调查分子交叉声和免疫逃避机制.
主要成果:
- 识别了卵泡状,EMT状和非分化的甲状腺细胞状态在"热"",冷"和"排除"免疫中.
- 没有覆盖的交叉 (SPP1-CD44,GAS6-AXL) 推动了上皮层-介质细胞过渡.
- 已证明VSIG4+巨细胞会损害瘤小岛中的T细胞活性和PD-L1表达.
结论:
- 单细胞洞察力正在通过揭示细胞异质性和免疫逃避来重塑TC免疫疗法.
- 新兴疗法包括组合检查点抑制和向细胞疗法.
- 基于瘤生态系统的个性化免疫治疗策略为改善TC结果提供了路线图.
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