在使用家用机械通风的COPD患者中,S3非侵入性通风问卷的临床重要差异最小
Pedro Viegas1, Leonor Roseta1, Cristina Jácome2,3
1Pulmonology Department, Unidade Local de Saúde de Gaia/Espinho, Vila Nova de Gaia, Portugal.
ERJ open research
|September 17, 2025
概括
在S3-非侵入性通风 (S3-NIV) 问卷中,对于在家用机械通风 (HMV) 的COPD患者,现在具有0.8分的临床重要差异 (MCID). 这一发现有助于跟踪症状变化和优化治疗,以更好地管理患者.
科学领域:
- 肺部医学 肺部医学
- 呼吸系统护理 呼吸系统护理
- 临床测量 临床测量
背景情况:
- S3-非侵入性通风 (S3-NIV) 问卷监测使用家庭机械通风 (HMV) 的患者的症状和副作用.
- 确定S3-NIV的最小临床重要差异 (MCID) 对HMV用户的纵向监测和治疗优化至关重要.
- 目前,S3-NIV问卷没有定义的MCID,这阻碍了其充分的临床实用性.
研究的目的:
- 确定S3-非侵入性通风 (S3-NIV) 调查问卷的临床重要差异 (MCID) 的最小值.
- 为了确定患有慢性阻塞性肺病 (COPD) 的个人在家用机械通风 (HMV) 时的MCID.
主要方法:
- 一项观察性研究对HMV的成年COPD患者进行了观察,在HMV门诊诊所进行评估.
- 在基线和6个月后,S3-NIV,严重呼吸不足 (SRI) 和圣乔治呼吸问卷 (SGRQ) 进行了管理.
- 使用基于分布和的方法计算MCID,并从加权平均值得出一个聚合的MCID.
主要成果:
- 包括99名参与者 (71%男性,平均年龄为72±9岁) 患有HMV的COPD.
- SRI和SGRQ问卷显示了与S3-NIV的显著相关性,作为有效的 (p<0.002).
- 对于S3-NIV问卷,共计MCID为0.8分.
结论:
- 在使用HMV的稳定COPD患者中,建议S3-NIV问卷中使用0.8分的最小临床重要差异 (MCID).
- 这种已建立的MCID将有助于识别症状和副作用的临床显著变化.
- 这些发现支持改善HMV的COPD患者的管理和量身定制的后续行动.
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