肺部参与类风湿性关节炎,一个前性研究
Antoine Froidure1,2, Marie Perrot1, Aleksandra Avramovska3
1Pulmonology Department, Cliniques Universitaires Saint-Luc, ERN-LUNG, Brussels, Belgium.
ERJ open research
|September 17, 2025
概括
早期类风湿性关节炎 (RA) 中肺部参与很常见,间歇性肺病 (ILD) 和肺气经常被观察到. 建议优先对老年男性进行查,这些男性有活跃的RA和肺功能减弱.
科学领域:
- 类风湿病学 类风湿病学
- 肺部病理学 肺部病理学
- 遗传学 是一个遗传学.
背景情况:
- 类风湿性关节炎 (RA) 可以影响肺部,但早期RA中各种肺部疾病的患病率尚不清楚.
- 一项多中心前性研究旨在调查早期RA患者的间歇性肺病 (ILD),肺气,支气管炎和结节.
研究的目的:
- 确定早期类风湿性关节炎患者中不同类型的肺部感染的患病率.
- 确定与肺部疾病相关的风险因素和预测因素,如ILD和RA中的肺气.
主要方法:
- 招募了258名RA患者 (疾病持续时间为1-10年) 进行全面的呼吸评估.
- 使用高分辨率计算机断层扫描 (HRCT),肺功能测试 (PFT) 和遗传分析.
- 集中审查HRCT扫描和统计分析以确定关联和预测因素.
主要成果:
- ILD,肺气和显著的空气陷的患病率分别为15%,20%和34%.
- 年龄较大,男性性别,较高的疾病活性,以及肺部对一氧化碳 (D_LCO) 的扩散能力较低与ILD和肺气有关.
- 预测ILD的预测因素包括年龄较大,高的疾病活动得分-28,类风湿性因子阳性,低的D_LCO和MUC5B变异;吸烟包年预测肺气.
结论:
- 肺部参与在早期的RA中很普遍,狭性支气管炎,肺气和ILD是常见的.
- 高龄,疾病失控,男性性别和D_LCO降低与ILD和肺气有关.
- 建议在高风险的RA亚群中进行有针对性的查.
相关概念视频
01:22Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
500
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
500
01:23Rheumatic Heart Disease I: Introduction
448
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
448
01:11Genome-wide Association Studies-GWAS
15.3K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
15.3K
01:21Rheumatic Heart Disease III: Medical Management
289
Rheumatic heart disease (RHD) management can be divided into two main strategies: prevention and long-term management.Primary PreventionPrimary prevention focuses on timely diagnosis and management of group A streptococcal pharyngitis to prevent acute rheumatic fever. The most widely used antibiotic for treating this condition is intramuscular benzathine penicillin G.Acute Rheumatic Fever TreatmentThe primary treatment goal for a patient diagnosed with acute rheumatic fever is to suppress the...
289
01:20Rheumatic Heart Disease IV: Nursing Management
276
AssessmentA comprehensive assessment is essential in managing a patient with rheumatic heart disease (RHD). Begin with obtaining a detailed medical history, including recent streptococcal infections, a history of rheumatic fever, or previously diagnosed rheumatic heart disease. Assess the patient for symptoms such as fever, chest pain, widespread joint pain (arthralgia), tachycardia, pericardial friction rub, muffled heart sounds, heart murmurs, peripheral edema, subcutaneous nodules, and...
276
01:20The JAK-STAT Signaling Pathway
12.1K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
12.1K