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自然杀手细胞介导的抗瘤免疫:分子机制和临床应用

Nanzhi Luo¹, Cong Chen¹, Wenjing Zhou¹

¹Department of Thoracic Surgery and Institute of Thoracic Oncology Frontiers Science Center For Disease-Related Molecular Network West China Hospital of Sichuan University Chengdu China.

|September 17, 2025

概括

自然杀手 (NK) 细胞是天生的抗瘤免疫的关键,但受到瘤微环境 (TME) 的影响. 恢复NK细胞功能的策略提供了有前途的癌症免疫治疗方法.

科学领域:

免疫学免疫学免疫学
癌症生物学癌症生物学
细胞和分子医学细胞和分子医学

背景情况:

自然杀手 (NK) 细胞是对瘤的关键先天性免疫作用者,利用细胞毒性,细胞因子分泌和受体相互作用.
瘤细胞功能是由瘤微环境 (TME) 内的复杂相互作用调节的,包括受体-连接体动态,细胞因子网络和代谢-表观遗传因素.

研究的目的:

审查TME中NK细胞功能障碍的分子机制.
综合目前的临床策略,旨在恢复NK细胞抗瘤活性.
为开发有效的NK细胞基础免疫疗法提供框架.

主要方法:

关于NK细胞功能障碍的分子机制的综合文献综述.
基于NK细胞的治疗策略的最新进展的综合.
对针对NK细胞恢复的临床方法的分析.

主要成果:

该TME诱导免疫抑制和代谢重编程,损害NK细胞监测和抗瘤功能.
失调的信号传递,代谢变化和表观遗传沉默有助于NK细胞功能障碍.
包括收养转移,CAR-NK工程和TME调制在内的各种策略在恢复NK细胞活动方面显示出希望.

结论:

了解NK细胞功能障碍机制对于推进癌症免疫治疗至关重要.
通过新的治疗策略恢复NK细胞细胞毒性,对治疗固体和血液性恶性瘤具有显著的潜力.
基于NK细胞的免疫疗法的合理设计可以克服治疗耐药性.

关键词:

在 NK 细胞中,NK 细胞是 NK 细胞.在此之前,TME的临床策略临床策略代谢重编程是指代谢重编程.分子交叉电流是分子交叉电流.

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