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Updated: Jan 17, 2026

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合成和评估Diphenylpyrazine循环氨基衍生物作为IP受体激活剂

Xianrong Cai1, Guoyi Lin1, Juan Tang1

  • 1School of Chemistry Engineering, Sichuan University of Science & Engineering, Zigong 643000, China.

ACS medicinal chemistry letters
|September 17, 2025
PubMed
概括

研究人员开发了新的IP受体激动剂来治疗肺动脉高血压 (PAH). 新型化合物6c-14S显示显著增强的功效和改善的药理动力学特性,为PAH治疗提供了潜力.

关键词:
反聚合性活动.双烯氨酸是循环氨基衍生物的衍生物.作为IP受体的激活剂.простациклин 是一种前环素.

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